Our studies suggest that PPP1R14B can be used as a prognostic biomarker for pan-cancer. Increased PPP1R14B expression correlated with poor prognosis and increased immune infiltration levels in myeloid-derived suppressor cells (MDSCs). Herein, we found that PPP1R14B was involved in the prognosis of pan-cancer and closely related to immune infiltration.
We used the TCGA project and GEO databases to perform pan-cancer analysis of PPP1R14B, including expression differences, correlations between expression levels and survival, genetic alteration, immune infiltration, and relevant cellular pathways, to investigate the functions and potential mechanisms of PPP1R14B in the pathogenesis or clinical prognosis of different cancers. There was also lack of pan-cancer evidence for the relationship between PPP1R14B and various tumor types based on abundant clinical data.
However, the function and mechanisms of PPP1R14B in tumor progression remain ill defined. Recent studies have shown that PPP1R14B was highly expressed in tumor tissues and patients with high expression of PPP1R14B had poor survival rates.
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